Macrophages, monocytes and fetal growth restrictio
- Conditions
- Fetal growth restriction
- Registration Number
- NL-OMON23444
- Lead Sponsor
- MCG
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 48
Inclusion Criteria
Informed consent
-18-40 years old
-Pregnant
-Gestational age (GA): 36-42 weeks
-Fetal growth restriction and adequate fetal growth
Exclusion Criteria
-Smoking
-BMI >30
-Immune related disorders
-Fever/illness within the last month
-Fertility treatment (ovulation induction, intra-uterine insemination (IUI), in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI))
-Major congenital abnormalities
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences in macrophage and monocyte numbers and phenotype in maternal blood, placenta and cord blood
- Secondary Outcome Measures
Name Time Method Functional status of macrophages and monocytes in maternal blood, placenta and cord blood in terms of cytokine secretion and response to pro- and anti-inflammatory triggers