Macrophages and monocytes in uncomplicated pregnancy and fetal growth restrictio

Recruiting

• Conditions: fetal growth problems; Fetal growth retardation; 10027665; 10016849

• Registration Number: NL-OMON51245
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 8 July 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 48

Inclusion Criteria

- Informed consent
- 18-40 years old
- Pregnant
- Gestational age (GA): 36-42 weeks
- Fetal growth restriction OR appropriate fetal growth

Exclusion Criteria

- Smoking
- Immune related disorders
- Fever/illness within the last month
- Fertility treatment (ovulation induction, intra-uterine insemination,
IVF-ICSI)
- Major congenital abnormalities

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Number and phenotype of macrophages and monocytes in maternal blood, placenta<br /><br>and cord blood</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Functional status of macrophages and monocytes: cytokine secretion and response<br /><br>to pro- and anti-inflammatory triggers </p><br>