Impact of a whole grain-rich diet on markers of metabolic syndrome
- Conditions
- obesityDiet and Nutrition - Obesity
- Registration Number
- ACTRN12608000517370
- Lead Sponsor
- Commonwealth Scientific and Industrial Research Organisation (CSIRO) Human Nutrition
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
Weight not greater than 150kg.
Metabolic syndrome (International Diabetes Federation (IDF) 2006 definition: waist circumference >94cm for men and 80cm for women plus 2 of the following: fasting Triglycerides>1.7 mmol/l, High Density Lipoprotein (HDL) cholesterol< 1.03 (male) or 1.29 (female) , blood pressure> 130/85 or on antihypertensive medication, fasting glucose >5.6mmol/L).
Participants must understand the procedures involved and agree to participate in the study by giving full informed, written consent.
No abnormality of clinical significance on medical history.
If female, not pregnant or breast feeding.
Coeliac disease or gluten intolerance.
Have Type 1 or 2 Diabetes.
Have proteinuria, a malignancy, or a history of metabolic disease such as liver, kidney, unstable cardiovascular, clinically significant respiratory or gastrointestinal disease that impairs normal functioning, or are pregnant or lactating.
Have high uncontrolled hypertension (resting recumbent blood pressure (BP) >160/100 mmHg).
History of heavy alcohol consumption (> 5 Standard drinks/day).
Currently on a weight reducing diet.
Unable to comprehend or cope with study requirements.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Continuous glucose monitoring system for 24-48hrs (CGMS)[Week 6 and week 14]
- Secondary Outcome Measures
Name Time Method fibrinolytic factors by blood analysis[Week 0, week 6, week 8 and week 14];insulin, glucose, Total Cholesterol, Triglycerides by blood analysis[Week 0, week 6 week 8 and week 14]