Treatment of iron overload in thalassemia patients
Phase 2
- Conditions
- Thalassemia.Beta thalassaemia
- Registration Number
- IRCT2016041627412N1
- Lead Sponsor
- Vice Chancellor for research of Urmia University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 36
Inclusion Criteria
Inclusion Criteria: Transfusion-dependent Thalassemia; Age more than three years; Serum ferritin level > 5,000 ng/L and progressively increasing undergoing chelating therapy with subcutaneous DFO
Exclusion Criteria
Severe liver, kidney or cardiac disease; Serious adverse events with DFO or DFP; Neutriphil count < 2000/L during the past 2 years; Platelet count < 100,000/L; History of arthropathy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum ferritin. Timepoint: before intervention and in 2, 4, 6, 8, 10 and 12 month intervals after intervention. Method of measurement: ng/mL.
- Secondary Outcome Measures
Name Time Method Complete blood count. Timepoint: before intervention and monthly for 12 month after intervention. Method of measurement: blood examination.