ISRCTN06805028已完成不适用
Insulin sensitisation to delay pubertal progression in girls: a pilot study in small-for-gestational-age (SGA) girls with an early-normal onset of puberty
Hospital Sant Joan de Deu (Spain)0 个研究点目标入组 22 人开始时间: 2005年10月5日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 22
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- Female
入选标准
- •1. Birthweight for gestational age below -1.5 standard deviation (SD)
- •2. Onset of breast development (Tanner stage 2, B2) between age 8-9 years and <12 months before study start
- •3. Height SD score (SDS) at enrollment at least 1 SD above mid-parental height
- •4. Height velocity >6 cm/year
- •5. Progressive puberty, as assessed by pelvic ultrasonography and by gonadotropin and steroid responses to gonadotropin releasing hormone (GnRH) agonist stimulation
排除标准
- •A family or personal history of diabetes mellitus; a history of precocious pubarche; evidence for thyroid dysfunction, Cushing syndrome, hyperprolactinemia or glucose intolerance; medication known to affect gonadal function or carbohydrate metabolism.
研究者
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