NCT01718392已完成不适用
Rehabilitation in Multiple Sclerosis: Influence of Exercise on Development of Insulin Resistance, Muscle Power and Aerobic Capacity
Hasselt University2 个研究点 分布在 1 个国家目标入组 45 人开始时间: 2011年3月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 45
- 试验地点
- 2
- 主要终点
- insulin sensitivity (insulin profile)
研究概览
简要总结
the purpose of this study is to investigate the development of insulin resistance in multiple sclerosis patients + explaining the effects of a combined training programme on insulin resistance, muscle power and aerobic capacity in multiple sclerosis patients
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosed MS according to the McDonald criteria
- •Expanded Disability Status Scale (EDSS) between 0.5 and 6
- •Be able to train 5 times in 2 weeks at the University
排除标准
- •Comorbidities like cardiovascular-, respiratory-, orthopaedic or metabolic diseases (like diabetes type 2)
- •Having had an relapse in a period of 3 months prior to the start of the intervention period
- •Having an relapse during the intervention period
- •Pregnancy and other contra indications for physical activity
- •Mental disorders
结局指标
主要结局
insulin sensitivity (insulin profile)
时间窗: change from baseline to 24 weeks
glucose and insulin concentration measurements in blood
次要结局
- walking performance(change from baseline to 24 weeks)
- aerobic capacity - lactate concentrations(change from baseline to 24 weeks)
- body composition(Change from baseline to 24 weeks)
- muscle strength of knee extensor(change from baseline to 24 weeks)
- cytokine profile(change from baseline to 24 weeks)
- Self-reported measures(Change from baseline to 24 weeks)
- muscle strength of knee flexor(change from baseline to 24 weeks)
- muscle strength of elbow flexor(change from baseline to 24 weeks)
- muscle strength of elbow extensor(change from baseline to 24 weeks)
- aerobic capacity(change from baseline to 24 weeks)
研究者
Bert Op't Eijnde
Professor
Hasselt University
研究点 (2)
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