NL-OMON44348
Completed
N/A
Cognitive impairment and functional reorganization in multiple sclerosis: The role of GABA and glutamate - GABA and glutamate in cognitive impairment in MS
Anatomie en Neurowetenschappen0 sites75 target enrollmentTBD
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Anatomie en Neurowetenschappen
- Enrollment
- 75
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •To participate in the MRI part of the study:
- •\- Clinically definite Relapsing Remitting or Secondary Progressive Multiple sclerosis
- •\- Sufficient visual acuity and motor performance to perform the MRI task
- •\- Between 18 and 60 years of age;To participate in the PET\-part of the study:
- •\- Minimum hemoglobin values of 8 g/dl for men and 7 g/dl for women
Exclusion Criteria
- •For the MRI\-part of the study:
- •\- MR contraindications
- •\- Neurological and/or psychiatric disorders (other than MS; e.g. depression, schizophrenia, alcohol or drug abuse)
- •\- For MS patients: the use of corticosteroids in the 4 weeks prior to inclusion. ;For the PET\-part of the study:
- •\- benzodiazepine use or other drug use that affects the benzodiazepine site on the GABA receptor system (e.g. imidazopyridines, pyrazolopryimidines en cyclopyrrolones) 6 weeks or less before the start of the study.
- •\- The use of GHB (gamma\-hydroxybutyrate)
- •\- In the case of pregnancy or breastfeeding
- •\- Insufficient haemoglobin value values as discussed in the inclusion criteria.
- •\- (a history of) significant cardiac disease
- •\- exposure to previous radiation leading to an annual cumulative dose of more than 10mSv
Outcomes
Primary Outcomes
Not specified
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