nravelling brain mechanisms of cognitive impairment in breast cancer patients during adjuvant endocrine treatment - Effects of hormonal treatment for breast cancer on brain and cognition

Radboud Universiteit Nijmegen0 个研究点目标入组 150 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

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•* Women of age * 18 years.
•* Histologically/cytologically confirmed adenocarcinoma of the breast followed by intended curative surgery and if indicated, also radiotherapy and chemotherapy.
•* ER + and/or PgR + receptor status.
•* Indication for treatment with tamoxifen or anastrozole according to the Dutch guidelines.
•* Disease-free, as defined by the absence of somatic disease activity parameters.
•* Accessible for follow-up for duration of study.
•* Karnofsky 80-100.
•* Written informed consent.

•* Palliative treatment or inflammatory breast cancer .
•* Evidence of distant metastasis (M1).
•* Concomitant or previous malignancies except for adequately treated carcinoma in situ of the uterine cervix or basal squamous cell carcinoma of the skin.
•* Hormone Replacement Therapy for treatment of menopausal symptoms, not stopped at least 4 weeks prior to inclusion in the study.
•* Current psychological or psychiatric treatment.
•* Treatment with anti-depressive drugs, anti-epileptic drugs, benzodiazepines.
•* Insufficient command of the Dutch language to fill out questionnaires.
•* Contra-indication for MR examinations (e.g. claustrophobia).

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