NL-OMON37354
Completed
Not Applicable
nravelling brain mechanisms of cognitive impairment in breast cancer patients during adjuvant endocrine treatment - Effects of hormonal treatment for breast cancer on brain and cognition
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- breast cancer
- Sponsor
- Radboud Universiteit Nijmegen
- Enrollment
- 150
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\* Women of age \* 18 years.
- •\* Histologically/cytologically confirmed adenocarcinoma of the breast followed by intended curative surgery and if indicated, also radiotherapy and chemotherapy.
- •\* ER \+ and/or PgR \+ receptor status.
- •\* Indication for treatment with tamoxifen or anastrozole according to the Dutch guidelines.
- •\* Disease\-free, as defined by the absence of somatic disease activity parameters.
- •\* Accessible for follow\-up for duration of study.
- •\* Karnofsky 80\-100\.
- •\* Written informed consent.
Exclusion Criteria
- •\* Palliative treatment or inflammatory breast cancer .
- •\* Evidence of distant metastasis (M1\).
- •\* Concomitant or previous malignancies except for adequately treated carcinoma in situ of the uterine cervix or basal squamous cell carcinoma of the skin.
- •\* Hormone Replacement Therapy for treatment of menopausal symptoms, not stopped at least 4 weeks prior to inclusion in the study.
- •\* Current psychological or psychiatric treatment.
- •\* Treatment with anti\-depressive drugs, anti\-epileptic drugs, benzodiazepines.
- •\* Insufficient command of the Dutch language to fill out questionnaires.
- •\* Contra\-indication for MR examinations (e.g. claustrophobia).
Outcomes
Primary Outcomes
Not specified
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