A study to assess the effect of supplemenatation of beta-hydroxy-beta-methyl butyrate (HMB) in patients undergoing heart surgery with cardiopulmonary bypass (CPB)
Not Applicable
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2023/04/051341
- Lead Sponsor
- The Madras Medical Mission, Chennai
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Elective Cardiac surgery using cardiopulmonary bypass
Patients with adequate LV function
Patients with mild to moderate LV dysfunction
Exclusion Criteria
Patients with
Severe LV dysfunction
Preexisting kidney disease
Preexisting liver disease
Smoking, drug/alcohol abuse
Hepatitis B & C infection
Endocrine disorders
Autoimmune disorders
Patients already on protein supplementation
Offpump cardiac surgeries
Patient refusal
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome of the study is to determine whether preoperative supplementation of Beta-Hydroxy-Beta-Methyl butyrate (HMB) improves the outcome in the elective cardiac surgery on cardiopulmonary bypass (CPB).Timepoint: The patient is assessed one day before supplemenation and 2 weeks after supplementation, and again on the first post operative day
- Secondary Outcome Measures
Name Time Method The secondary outcome of the study is to determine the duration of ICU stay, mechanical ventilation, wound infections and post op complications. <br/ ><br> <br/ ><br>Timepoint: The patient is assessed one day before supplementation and 2 weeks after supplementation and again on the first post operative day.