Pharmacodynamic Modelling of the Sedative Effects of Dexmedetomidine with target- controlled infusion in Patients undergoing Spinal Anesthesia
- Conditions
- Diseases of the musculo-skeletal system and connective tissue
- Registration Number
- KCT0003601
- Lead Sponsor
- Hallym University Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 45
1. Patients who were scheduled for elective surgery within 3 hours under spinal anaesthesia
2. Patient who with American Society of Anesthesiologists grades I-III
3. Patients with aged 19-70 year
4. Patients who voluntarily agreed to be enrolled to the clinical research and signed written informed consent
1. Patients who has cardiovascular disease (arrthymia, ischemic heart disease, myocardical infarction, heart failure)
2. Patients who has neurovascular disease
3. Patients who has a history of drug use that could affect the central nervous system
4. Patients who has a history of adverse reactions to anesthetic agents
5. Pregnant female, or female who breast-feeds her baby
6. Other in-appropriative patients under the researcher's decision.
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method sedation level score using Modified Observer’s Assessment of Alertness/Sedation (MOAA/S); (1== does not respond to mild prodding or shaking; 2 = responds only after mild prodding or shaking; 3 = responds only after name is called loudly or repeatedly; 4 = lethargic response to name spoken in normal tone; 5 = responds readily to name spoken in normal tone)
- Secondary Outcome Measures
Name Time Method Bispectral index;Heart rate;Blood pressure;oxygen saturation(SpO2)