Analgesic, Sedative and Antibiotic Pharmacokinetics during Extracorporeal Membrane Oxygenation: Understanding altered pharmacokinetics to improve patient outcomes.
Not Applicable
Recruiting
- Conditions
- Alterations to the pharmacokinetics of sedative and analgesic drugs and their metabolites (morphine - morphine 3 glucorunide, morphine 6 glucuronide, midazolam - 1 and 4 hydroxy midazolam, fentanyl - norfentanyl, dexmedetiomedine, propofol, thiopentone) in critically ill patients receiving ECMO.Alterations to the pharmacokinetics of broad spectrum antibiotics (ceftriaxone, cefepime, meropenem, gentamicin, ciprofloxacin, ticarcillin-clavulanate, piperacillin-tazobactum, vancomycin, linezolid, caspofungin, fluconazole, voriconazole, oseltamivir/oseltamivir carboxylate) in critically ill patients receiving ECMO.Cardiovascular - Other cardiovascular diseasesRespiratory - Other respiratory disorders / diseasesAnaesthesiology - Anaesthetics
- Registration Number
- ACTRN12612000559819
- Lead Sponsor
- Critical Care Research Group
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 160
Inclusion Criteria
Currently undergoing ECMO for respiratory +/- cardiac dysfunction
- Clinical indication for the antibiotics ceftriaxone, cefepime, meropenem, gentamicin, ciprofloxacin, ticarcillin-clavulanate, piperacillin-tazobactum, vancomycin, linezolid, caspofungin, fluconazole, voriconazole and oseltamivir
- Clinical indication for the sedatives and analgesics morphine, fentanyl, midazolam, dexmedetomidine, propfol or thiopentone
Exclusion Criteria
- No valid consent
- Known allergy to study drug
- Pregnancy
- S. Bilirubin >150
- Ongoing massive blood loss and blood product transfusion
- Therapeutic plasma exchange in the last 24 hours.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method