Obesity and asthma: Effect of bariatric surgery on lung function, inflammation and quality of life.
Completed
- Conditions
- asthma, obesityastma, obesitas
- Registration Number
- NL-OMON24901
- Lead Sponsor
- Sint Franciscus Gasthuis, Rotterdam, The Netherlands and Leiden University Medical Center, Leiden, The Netherlands
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
1. For the asthma patients: Physician diagnosed, persistent asthma > 2 years;
2. Age > 18 and < 50 year;
Exclusion Criteria
1. Smoking > 10 sig/d or > 10 pack years (PY);
2. COPD or other pulmonary pathology apart from asthma;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ung function: FEV1/FVC at 12 months after bariatric surgery.
- Secondary Outcome Measures
Name Time Method 1. Other lung function parameters: FEV1, FIV1, TLC, FRC, reversibility (supine and sitting position). R5, X5 and Fres (FOT);<br /><br>2. Airway inflammation: FeNO, bronchial biopsies (during operation), PC20 methacholine;<br /><br>3. Systemic inflammation (blood): TNF-á, IL-6, eotaxin, high sensitivity CRP, leptin, adiponectin, oestrogen, progesteron, lipid spectrum, glucose, sCD14;<br /><br>4. Local inflammation (visceral fat tissue and bronchial biopsies): determination of gene expression (TNF-á, IL-6, eotaxin, leptin, adiponectin), polymorphisms of Beta-2 receptor ADRB2, glucocorticoid receptor gen NR3C1 and Toll-like receptors (TLR2, TLR4, TLR6 en TLR10, and IgE. Intima Media Thickness measurement. Determination of structural features in bronchial mucosa (airway remodelling);<br /><br>5. Asthma symptoms: ACQ, exacerbation frequency, medication use, ACT.