Platelet Function With Various Storage Techniques

Phase 2

Withdrawn

• Conditions: Platelet Dysfunction Due to Drugs
• Interventions: Biological: Placebo; Biological: Infusion of Platelets

• Registration Number: NCT03338660
• Lead Sponsor: Northwell Health

Brief Summary

Platelet function will be tested in individuals on antiplatelet medications to determine the optimal storage methodology.

Detailed Description

Subjects will undergo administration of antiplatelet drugs and then will receive platelets stored in a variety of methods. Platelet function will be measured serially.

Study Timeline

• Study First Submitted: 2017-02-01
• Study First Submitted QC: 2017-11-08
• Study First Posted: 2017-11-09
• Study Start: 2018-07-15
• Status Verified: 2019-05
• Last Update Submitted: 2019-05-24
• Last Update Posted: 2019-05-29
• Primary Completion: 2019-07-15
• Study Completion: 2020-07-15

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Normal subjects

Exclusion Criteria

• Pre existing antiplatelet drugs

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Control (Placebo)	Placebo	Subjects will receive infusion of placebo (saline).
Platelet storage routine	Infusion of Platelets	Subjects will receive infusion of platelets stored by routine method.
Platelet storage experimental	Infusion of Platelets	Subjects will receive infusion of platelets stored by a novel methodology.

Primary Outcome Measures

Name	Time	Method
Change in platelet function	1 hour post-transfusion	Frozen platelets will result in improvement in platelet function after transfusion.