Prevalence and Clinical Presentation of Functional Neurological Disorders in Patients With Movement Disorders - A Cross-sectional Study in the Movement Disorders Clinic of the Department of Neurology, Medical University of Graz
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Conversion Disorder
- Sponsor
- Medical University of Graz
- Enrollment
- 216
- Locations
- 1
- Primary Endpoint
- Functional neurological symptoms
- Status
- Recruiting
- Last Updated
- 7 months ago
Overview
Brief Summary
The goal of this observational study is to learn about functional neurological disorders in patients with common non-functional movement disorders ("functional overlay"). The main questions it aims to answer are:
- What is the frequency of functional neurological disorders in patients with non-functional movement disorders (functional overlay)?
- What are the characteristics of functional neurological disorders in patients with non-functional movement disorders?
Participants will be examined clinically and electrophysiologically, the examinations consist of:
- a neurological examination
- neuropsychological testing
- electrophysiological tremor diagnostic
- questionnaires about psychological, biological and social risk factors
Researchers will compare patients with functional motor disorders to patients wit non-functional movement disorders to see if they differ from each other regarding the functional symptoms.
Detailed Description
Functional neurological disorders (FND) are common neurological disorders that are present in up to 16% of patients in neurological outpatient clinics. They are associated with a significant reduction in quality of life, can lead to permanent impairment, and have a poor prognosis, especially if the diagnosis is delayed. FND have multifactorial causes and risk factors, including psychological stressors, childhood trauma, female gender, psychiatric disorders such as depression, anxiety disorder, or post-traumatic stress disorder, and other functional disorders such as irritable bowel syndrome or chronic pain syndrome. Patients with FND often report additional cognitive complaints ("cognitive fog"). A mismatch of various regulatory mechanisms, a disruption of sensory processing and motor output is assumed to be a central part of the pathogenesis. A characteristic feature of FND is a variability of symptoms according to attention. FND can be intensified by increased attention and weakened by distraction. Positive diagnostic criteria for FND have been established recently, so that by definition FND are no longer a diagnosis of exclusion. The clinical presentations of FND are diverse and include impaired limb movement control, disturbances in vigilance that may be associated with seizures, and non-motor symptoms. FND often coincide and often coexist with pain, fatigue, sleep disorders, and cognitive disorders. Particularly non-motor functional symptoms are highly debilitating for patients. The coincidence of "organic" neurological disorders and FND in the same patients ("functional overlay") is probably not uncommon, but has been investigated primarily in patients with Parkinson's Disease and epilepsy, so far. However, it is important to recognize FND in patients with movement disorders in order to treat them adequately and to protect them from incorrect treatment (surgery, unnecessary medication, etc.). However, the basic prerequisite for this is an exploration of the frequency and characteristics of the functional symptoms in movement disorders.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Functional or non-functional movement disorder
- •18 to 80 years
Exclusion Criteria
- •Patient is not able to consent
- •Patient is not able to understand / speak German fluently (questionnaires are available only in German)
Outcomes
Primary Outcomes
Functional neurological symptoms
Time Frame: on average 30 minutes
Diagnosed by positive signs for functional neurological symptoms, as assessed in the neurological examination
Secondary Outcomes
- Functional cognitive symptoms(up to 60 minutes)
- Trauma in childhood(up to 10 minutes)
- Visuospatial abilities(up to 15 minutes)
- Tremor diagnostic(up to 20 minutes)
- General anxiety(3 minutes)
- Somatic symptoms(5 minutes)
- Work ability(5 minutes)
- Subjective quality of life(5 minutes)
- Fatigue(up to 5 minutes)
- Duration of anamnesis(1 to 3 minutes)
- Subjective health(up to 10 minutes)
- Depression(3 minutes)
- Personality traits(up to 10 minutes)
- Executive function(up to 10 minutes)
- Memory(up to 15 minutes)
- phonematic word fluency(2 minutes)
- Personality functioning(up to 15 minutes)
- Psychosomatic Competence(up to 10 minutes)
- Attachment styles(5 minutes)
- Alexithymia(5 minutes)
- Semantic word fluency(2 minutes)