Stepwise medical treatment of Cushing's disease
Recruiting
- Conditions
- Hypercortisolism due to Cushing's disease
- Registration Number
- NL-OMON20587
- Lead Sponsor
- Erasmus MCDpt. of Internal Medicine, Endocrine SectionRotterdamThe Netherlands
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 16
Inclusion Criteria
1. Both naïve patients with Cushing’s disease and patients with residual hypercortisolism after recent transsphenoidal adenomectomy are eligible for enrolment.
2. Finally, patients with recurrent Cushing’s disease can also be included.
Exclusion Criteria
1. Patients with poorly controlled diabetes mellitus indicated by a HbA1c % > 8.5 %.
2. Patients with a disturbed liver function indicated by serum bilirubin, ALAT, ASAT or alkaline phosphatase levels > 2.5 x ULN.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Achievement of normocortisolism
- Secondary Outcome Measures
Name Time Method - Improvement of clinical symptoms of Cushing's disease<br /><br>- Quality of life<br /><br>- Glucose tolerance<br /><br>- Pituitary adenoma size<br /><br>- Bone metabolism (bone mineral density, bone formative and resorptive markers)<br /><br>- Hemostasis