Strength training for the treatment of Cushing's associated myopathy: a randomised study
- Conditions
- E24.9G73.5Cushing syndrome, unspecifiedMyopathy in endocrine diseases
- Registration Number
- DRKS00024575
- Lead Sponsor
- Medizinische Klinik und Poliklinik IV, LMU Klinikum München
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 42
Cushing's syndrome:
- path. Dexamethasone inhibition test
- path. 23 o'clock salivary cortisol level
- path. 24h-collection urine cortisol (>2.0 UNL)
- planned surgery
- Confirmed subtype: adrenal, pituitary or ectopic
Cushing's syndrome in long-term remission:
- Successfully treated Cushing's syndrome
- Persisting functional impairment
Metabolic syndrome:
- Functional impairment
- Exclusion of hypercortisolism
- Central obesity and at least 2 of the following criteria: Serum triglycerides < 150 mg/dl; reduced serum HDL cholesterol < 50 mg/dl; art. Hypertension (> 130/85mmHg); elevated fasting blood glucose (> 100mg/dl) or type II diabetes - or drug treatment of any of these symptoms
- Age under 18 years or over 60 years
- Contraindication to surgery
- Existing pregnancy
- Chronic general illness
- Alcohol or drug abuse
- Physical limitation to participate in the exercise program
- Participation in another interventional clinical trial
- Life expectancy of less than one year
- Myocardial infarction within the past 3 months
- Cardiopulmonary instability or ischemia signs during exercise testing
- Cytostatic therapy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Grip strength after 6 month Intervention (at the time 7 months after baseline/Operation)
- Secondary Outcome Measures
Name Time Method Muscle function, diastolic dysfunction, body composition and muscle mass, quality of life