The biology of ageing in relation to acute myeloid leukemia (AML) in older patients
Completed
- Conditions
- AML10024324
- Registration Number
- NL-OMON39102
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 75
Inclusion Criteria
- a doctor's diagnosis of normal general health
- not suffer from a hematological disease
- people older than 60 years of age who get a total hip replacement
- healthy volunteer < 35 years
- heatlhy potential donor who undergoes a routine bone marrow aspirate as part of the standard medical examination
Exclusion Criteria
- patients suffering from a hematological disease
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>We aim to identify molecular pathways which are activated upon ageing to<br /><br>protect stem cells against damage but are down-regulated in AML cells of older<br /><br>patients.</p><br>
- Secondary Outcome Measures
Name Time Method <p>We aim to explore whether oncogenic hits have different molecular and cellular<br /><br>consequences depending on the age of the target cell.</p><br>