Effects of low salt weight loss diets on the way blood vessels work

Not Applicable

Completed

• Conditions: Overweight or obese; Blood vessel function: flow mediated dilatation, pulse wave velocity and augmentation and blood pressure; Diet and Nutrition - Obesity

• Registration Number: ACTRN12614001334695
• Lead Sponsor: niversity of South Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-12-18
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

overweight to obese (BMI greater than or equal to 27 kg/m2) men and women, weight stable within the last 6 months, BP (SBP) <160 mmHg and (DBP) <90 mmHg

Exclusion Criteria

BMI less than 27 kg/m2, serious illness e.g. Cancer, liver or kidney disease or not willing or able to follow diet for the study period, alcohol intake above 1 standard drink/day and not willing to decrease intake

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Flow mediated dilatation (FMD) of the brachial artery will be measured using ultra sound<br>[baseline, 8 weeks after either control or weight loss and after 2 weeks weight stability];Pulse wave velocity (PWV) and augmentation index(AI) will be measured using a SphygmoCor Registered Trademark XCEL (AtCor Medical)[Baseline, 8 weeks weight loss/ controlm period and after 2 weeks weight stability];Blood pressure (BP) will be measured using and automated sphygmomanometer[baseline, 8 weeks after either control or weight loss and after 2 weeks weight stability]

Secondary Outcome Measures

Name	Time	Method
24h urine sodium, potassium will be measures in a certified commercial laboratory[baseline, 8 weeks after either control or weight loss and after 2 weeks weight stability];Bloods for Plasma sodium & potassium, nitrates/nitrites, ICAM-1 & VCAM-1, E-selectin & endothelin-1[baseline, 8 weeks after either control or weight loss and after 2 weeks weight stability];Weight, height and waist circumference[All visits]