NCT03943849撤回不适用
The Use of Dental Pulp Tissue as an Autogenous Graft for Ridge Augmentation
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- Bone fill as assessed by radiograph
研究概览
简要总结
The purpose of this study is to examine and compare the effects of autogenous dental pulp tissue on bone formation in the extraction sockets as compared to commonly used particulate bone graft. The effects on bone formation will be examined using a wide variety of assays.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •American Society of Anesthesiologists (ASA) Physical Status Classification System ASA 1 (A normal healthy patient) or ASA 2 (A patient with mild systemic disease)
- •never smoker
- •patients with planned tooth extraction
- •intact extraction sockets
- •no medication or antibiotics intake for at least 6 months prior to the procedure
- •patients who gave their consent to participate in the study.
排除标准
- •vulnerable subjects (children, pregnant and lactating women, patients with learning disabilities, and prisoners)
- •inability to obtain pulp tissue (for example, due to previous endodontic therapy, obliterated pulp canals)
结局指标
主要结局
Bone fill as assessed by radiograph
时间窗: 4 months after placement of bone graft
次要结局
- Extent of mineralization as assessed by von Kossa staining(4 months after placement of bone graft)
- Extent of mineralization as assessed by Xylenol Orange staining(4 months after placement of bone graft)
- Expression of osteoblastic marker BSP assessed by immunostaining using anti-BSP antibody(4 months after placement of bone graft)
- Expression of osteoblastic marker Bglap assessed by quantitative PCR (qPCR)(4 months after placement of bone graft)
- Expression of osteoblastic marker Bsp assessed by quantitative PCR (qPCR)(4 months after placement of bone graft)
- Expression of osteoblastic marker BGLAP assessed by immunostaining using anti-BGLAP antibody(4 months after placement of bone graft)
- Expression of osteoblastic marker DMP1 assessed by immunostaining using anti-DMP1 antibody(4 months after placement of bone graft)
- Expression of osteoblastic marker Sost assessed by quantitative PCR (qPCR)(4 months after placement of bone graft)
- Expression of osteoblastic marker Dmp1 assessed by quantitative PCR (qPCR)(4 months after placement of bone graft)
- Expression of osteoblastic marker Col1a1 assessed by quantitative PCR (qPCR)(4 months after placement of bone graft)
研究者
Karo Parsegian
Assistant Professor
The University of Texas Health Science Center, Houston
研究点 (2)
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