Analgesic Effect of Quadratus Lumborum Block in Laparoscopic Hemicolectomy
Not Applicable
- Conditions
- Post Operative Pain
- Interventions
- Procedure: Quadratus lumborum block
- Registration Number
- NCT04848363
- Lead Sponsor
- Petrovsky National Research Centre of Surgery
- Brief Summary
Comparison of the effectiveness: Quadratus lumborum (QL) block by levobupivacaine with placebo.
- Detailed Description
All patients will receive standard anaesthesia using fentanyl, protocol, cisatracurium and sevoflurane. Prevention of nausea and vomiting is performing using Apfel score.
All patients will receive post operative multimodal analgesia using paracetamol, ketoprofen, tramadol, and trimeperidine if numerical rating scale \> 3 The study assumes use of QL block by levobupivacaine.in comparison with placebo in order to demonstrate the effectiveness of QL block during the operation.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- Patients who have undergone left-sided or right-sided laparoscopic hemicolectomy.
- Patient's willingness and ability to sign an informed consent document
Exclusion Criteria
- Allergy to local anesthetics
- Chronic pain syndrome and associated opioid use.
- Coagulopathy
- Uncontrolled diabetes mellitus
- Physical Status Classification System scale above 3
- Diseases associated with the pathology of the hypothalamus
- Diseases associated with the pathology of the pituitary gland
- Diseases associated with the pathology of the adrenal glands
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Study group Quadratus lumborum block patients receiving general anesthesia with propofol, fentanyl and cisatracurium for induction and sevoflurane, fentanyl and cisatracurium for maintaining anesthesia. Patients receiving postoperative multimodal intravenous analgesia with paracetamol, ketoprofen, tramadol, and trimeperidine. In this group, after induction of anesthesia before the operation, bilateral blockade of the square dorsi muscle is performed under ultrasound guidance using 20 ml of a solution of levobupivacaine 2.5 mg / ml. Control group Quadratus lumborum block patients receiving general anesthesia with propofol, fentanyl and cisatracurium for induction and sevoflurane, fentanyl and cisatracurium for maintaining anesthesia. Patients receiving postoperative multimodal intravenous analgesia with paracetamol, ketoprofen, tramadol, and trimeperidine. In this group, after induction of anesthesia before surgery, bilateral blockade of the square dorsi muscle is performed under ultrasound guidance using 20 ml of saline.
- Primary Outcome Measures
Name Time Method NRS (Numeric rating scale) two hours after surgery NRS scale 0-10, "no pain"; 10, "worst pain imaginable"
- Secondary Outcome Measures
Name Time Method The need for antiemetic drugs to relieve postoperative nausea and vomiting 12 hours after the surgery Occurrence of prolonged post-operative ileus first two weeks after surgery The need for opioid analgesics for postoperative pain relief 72 hours after surgery Blood glucose level after induction into anesthesia, immediately after the end of the surgery, 12 hours after the surgery The need for opioid analgesics during surgery on operations The level of prolactin in the blood after induction into anesthesia and immediately after the end of the surgery. The level of blood lactate after induction into anesthesia, immediately after the end of the surgery, 12 hours after the surgery The level of cortisol in the blood after induction into anesthesia and immediately after the end of the surgery
Trial Locations
- Locations (1)
Petrovsky Research National Centre of Surgery ( Petrovsky NRCS)
🇷🇺Moscow, Russian Federation