Remote ischemic preconditioning for renal protection during partial nephrectomy
Not Applicable
- Conditions
- Kidney Neoplasm
- Registration Number
- JPRN-UMIN000030305
- Lead Sponsor
- Tokyo Women's Medical University
- Brief Summary
Of the 59 patients with RIPC and 482 without RIPC, 53 each were matched by propensity score. There were no significant differences in the postoperative eGFR in mL/min/1.73m2 at nadir (mean difference 3.8, 95% CI -2.8-10.4) and its % change from baseline (mean difference 4.7, 95% CI -1.6-11.1) between the two groups. The sensitivity analysis also showed no significant differences.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 59
Inclusion Criteria
Not provided
Exclusion Criteria
1. No limbs 2. Peripheral vascular disease affecting lower limbs 3. Peripheral nerve injury affecting lower limbs 4. Bleeding tendency 5. Cognitive disorder 6. Mental disorder requiring treatment 7. Poorly controlled diabetes (HbA1c >= 7.0%) 8. Drug therapy with sulfonamide or nicorandil 9. Pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The nadir estimated glomerular filtration rate (mL/min/1.73m2) within 7 days of operation
- Secondary Outcome Measures
Name Time Method The incidence of acute kidney injury; Estimated glomerular filtration rate (mL/min/1.73m2) at 1, 3 and 6 months after operation; Operation time; Ischemic time; Estimated blood loss; Adverse events