Dietary Lipids as Primary Modulators of Carotenoid Absorption in Vegetables

Not Applicable

Completed

• Conditions: Absorption of Carotenoids From Vegetables
• Interventions: Other: Soybean Oil; Other: Canola Oil; Other: Butter

• Registration Number: NCT01006174
• Lead Sponsor: Purdue University

Brief Summary

The purpose of this research study is to determine how dietary fats and oils influence the absorption of beneficial plant pigments (carotenoids) from vegetables. The study will examine changes in blood carotenoids in response to eating a salad with different fats/oils.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-03
• Study First Submitted: 2009-10-30
• Study First Submitted QC: 2009-10-30
• Study First Posted: 2009-11-01
• Primary Completion: 2010-02
• Study Completion: 2010-05
• Status Verified: 2013-01
• Last Update Submitted: 2013-01-16
• Last Update Posted: 2013-01-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 55

Inclusion Criteria

• Age range: 18-50 years.
• Body mass index (BMI: weight (kg)/height (m2)) ranging from 20-29 kg/m²
• Weight stable (<4.5 kg change within the last 3 months),
• Constant habitual activity pattern, not to exceed activities of a recreational level over the past 3 months.
• Must be pre-menopausal
• Have clinically normal blood profiles (specifically normal liver and kidney functions and fasting blood glucose of ≤110 mg/dl)
• Non-smoking
• Non-diabetic
• No current or planned pregnancy
• Not using any hormone-based contraceptive, e.g., pill, patch, injection, implants, etc.
• No current use of medication affecting lipid profile
• No intestinal disorders including lipid malabsorption, lactose intolerance
• No heavy consumption of alcohol (>2 drinks per day)
• No current use of dietary supplements that affect cholesterol, (e.g. Benocol or fiber supplements) or a willingness to discontinue their use during the study.

Exclusion Criteria

• Menopausal
• Diabetic
• Currently pregnant
• Currently using any type of hormone-based contraceptives, (e.g., pill, patch, injection, implants, etc.)
• Use of lipid altering medications

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
A	Soybean Oil	Subjects will be assigned to consume 3 grams soybean oil, 8 grams canola oil, and 20 grams butter that is added to a salad.
A	Canola Oil	Subjects will be assigned to consume 3 grams soybean oil, 8 grams canola oil, and 20 grams butter that is added to a salad.
A	Butter	Subjects will be assigned to consume 3 grams soybean oil, 8 grams canola oil, and 20 grams butter that is added to a salad.
B	Soybean Oil	Subjects will be assigned to consume 8 grams soybean oil, 20 grams canola oil, and 3 grams butter that is added to a salad.
B	Canola Oil	Subjects will be assigned to consume 8 grams soybean oil, 20 grams canola oil, and 3 grams butter that is added to a salad.
B	Butter	Subjects will be assigned to consume 8 grams soybean oil, 20 grams canola oil, and 3 grams butter that is added to a salad.
C	Soybean Oil	Subjects will be assigned to consume 20 grams soybean oil, 3 grams canola oil, and 8 grams butter that is added to a salad.
C	Canola Oil	Subjects will be assigned to consume 20 grams soybean oil, 3 grams canola oil, and 8 grams butter that is added to a salad.
C	Butter	Subjects will be assigned to consume 20 grams soybean oil, 3 grams canola oil, and 8 grams butter that is added to a salad.

Primary Outcome Measures

Name	Time	Method
Evaluating the impact of dietary lipid profiles on intestinal absorption of carotenoids from vegetables.	66 days

Trial Locations

Locations (1)

Purdue University; 🇺🇸 West Lafayette, Indiana, United States