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Blood Biomarker of Alzheimer's Disease (AD)

Completed
Conditions
Alzheimer Disease
Registration Number
NCT03340571
Lead Sponsor
Duke University
Brief Summary

Currently, no cures or disease modifying therapies exist for Alzheimer's disease (AD). This is partially due to the inability to detect the disease before it has progressed to a stage where there are clinical manifestations. The identification and validation of high throughput biomarkers to measure disease progression (as well as identify pre-clinical disease onset) is critical to the development of disease-modifying or even preventative therapies. In this study, we are testing a blood biomarker for stratification of Alzheimer's disease patients and healthy volunteers. This study may lead to future blood tests that may help earlier diagnosis of Alzheimer's disease and detect the disease progression.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
21
Inclusion Criteria

Alzheimer's Disease Patients:

  • 50 years and older
  • AD patient who is seen at the Memory Disorders Clinic
  • AD diagnosis
  • Non smoking
  • No cancer treatment in the last 5 years
  • Informed consent from the patient or the patient's legally authorized representative (LAR)
  • Patient and/or LAR able to read and speak English

Healthy Control Participants:

  • 50 years and older
  • Non smoking
  • No cancer treatment in the last 5 years
  • Age matched to AD subject
  • Able to read and speak English
Read More
Exclusion Criteria

Alzheimer's Disease Patients:

  • Known additional neurological disease

Healthy Control Participants:

  • Neurological degenerative diseases (such as Parkinson's, Alzheimer's or Huntington's)
Read More

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Biological marker of Alzheimer's diseaseDay 1

Test for blood biological marker of Alzheimer's disease, mtDNA damage

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Duke University

🇺🇸

Durham, North Carolina, United States

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