Epidemiological Study of Korean Radiation Workers

Active, not recruiting

• Conditions: Leukemia, Radiation-Induced; Neoplasms, Radiation-Induced; Radiation Effects; Occupational Exposure to Radiation
• Interventions: Radiation: Occupational radiation exposure

• Registration Number: NCT05380570
• Lead Sponsor: Korea Institute of Radiological & Medical Sciences

Brief Summary

Health risks of radiation exposure in the moderate-to-high dose range have been well established. However, the risk remains unclear at low-dose ranges with protracted low-dose rate exposure, which is typical of occupational exposure. The purpose of this study is to construct a cohort of Korean radiation workers and to assess health effects associated with occupational radiation exposure. The study population is expected to be about 190,000 Korean radiation workers who have been registered with the Nuclear Safety and Security Commission since 1984. The national dose registry, the national cancer registry, the national vital statistics registry, and the national health insurance data are collected based on the Nuclear Safety Act. Through the linkage of those collected data, we will evaluate radiation-induced health risks including cancer and non-cancer diseases.

Detailed Description

The study population of this study is approximately 190000 Korean radiation workers registered with the Nuclear Safety and Security Commission since 1984. Diagnostic medical radiation workers were not included in the study population. The national dose registry, the national cancer registry, the national vital statistics registry, and the national health insurance data for radiation workers are collected retrospectively or prospectively based on the Nuclear Safety Act. Through the linkage of those collected data, we will evaluate radiation-induced health risks including cancer and non-cancer diseases. This data collection will be continued at 5-year intervals to update information on existing study participants and recruit newly hired workers if possible.

Age- and sex-specific standardized incidence and mortality ratios will be calculated for overall comparisons of cancer and non-cancer disease risks with general population. For dose-response assessment, excess relative risk (per Gy) and excess absolute risk (per Gy) will be estimated with adjustments for age and potential confounders, such as lifestyle factors and socioeconomic status.

Study Timeline

• Study Start: 2021-11-18
• Study First Submitted: 2022-05-09
• Study First Submitted QC: 2022-05-13
• Study First Posted: 2022-05-19
• Primary Completion: 2022-12-31
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-03
• Last Update Posted: 2025-03-05
• Study Completion: 2031-03-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 196379

Inclusion Criteria

• Korean radiation workers in the national dose registry (except for diagnostic medical radiation workers)

Exclusion Criteria

• Unidentified personal identification numbers
• Foreigner

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Korean radiation workers	Occupational radiation exposure	The study population is Korean radiation workers exposed to ionizing radiation in workplaces. Diagnostic medical radiation workers were not included in the study population.

Primary Outcome Measures

Name	Time	Method
Radiation-induced cancer risk	year 9	Cancer risk associated with occupational radiation exposure

Secondary Outcome Measures

Name	Time	Method
Radiation-induced non-cancer risk	year 9	Non-cancer disease risk associated with occupational radiation exposure

Trial Locations

Locations (1)

Korea Institute of Radiological & Medical Sciences; 🇰🇷 Seoul, Nowon-gu, Korea, Republic of