Changes in Metabolic Status in Patients With Total Thyroidectomy

• Conditions: Thyroid Cancer

• Registration Number: NCT01781767
• Lead Sponsor: Tel-Aviv Sourasky Medical Center

Brief Summary

This study objective is to evaluate the change in mitochondrial uncoupling protein 2 (UCP2) mRNA expression as function of thyroid activity (TSH, T3 and Free T4).

Detailed Description

Blood will be drown before thyroidectomy, 2 weeks after the operation and 3-4 month after the operation.

Study Timeline

• Status Verified: 2013-01
• Study Start: 2013-01
• Study First Submitted: 2013-01-27
• Study First Submitted QC: 2013-01-30
• Last Update Submitted: 2013-01-30
• Study First Posted: 2013-02-01
• Last Update Posted: 2013-02-01
• Primary Completion: 2014-07
• Study Completion: 2014-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Patients who were diagnosed with thyroid carcinoma and are going to have total thyroidectomy.
• Patients with unbalanced thyroid hormones.
• Aged 18-65 years at the time of screening.
• Provision of written informed consent.

Exclusion Criteria

• Patients with Diabetes.
• Patients with any other chronic inflammatory diseases.
• Steroid treatment.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in UCP2 mRNA concentrations.	Base line (before opporation), 2 weeks after opporation and for after opporation.	The difference between the result at two weeks and four months compare to base line.

Secondary Outcome Measures

Name	Time	Method
Weight	Approximately 4 months
Resting energy expenditure	Approximatly 4 months

Trial Locations

Locations (1)

Tel Aviv Sourasky Medical Center; 🇮🇱 Tel Aviv, Israel