Evaluation of The Effect of N-acetylcysteine in The Prevention of Vancomycin-Induced Renal Disorder
Phase 3
Recruiting
- Conditions
- .
- Registration Number
- IRCT20150721023282N6
- Lead Sponsor
- Esfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Take colistin at a dose of 4.5 million units every 12 hours
Creatinine Clearance > 90 ml/min (Based on CKD-EPI Formula)
Exclusion Criteria
Underlying kidney disorder
Receiving other nephrotoxic drugs
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum Creatinine. Timepoint: At baseline and 2, 4, 6, 8, and 10 days after initiation of intervention. Method of measurement: Spectrophotometry.;Blood Urea Nitrogen. Timepoint: At baseline and 2, 4, 6, 8, and 10 days after initiation of intervention. Method of measurement: Spectrophotometry.;Creatinine Clearance. Timepoint: At baseline and 2, 4, 6, 8, and 10 days after initiation of intervention. Method of measurement: CKD-EPI Formula.;NGAL serum level. Timepoint: At baseline and 5 days after initiation of intervention. Method of measurement: NGAL Measurement Kit.;The number of patients with acute kidney injury. Timepoint: End of intervention. Method of measurement: counting.
- Secondary Outcome Measures
Name Time Method