Postprandial effects of a low vs. a high glycemic index food product on metabolic risk markers in lean and obese me

Completed

• Conditions: fatty degeneration; obesity; 10018424

• Registration Number: NL-OMON31524
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Lean (BMI 20-25kg/m²) as well as obese (BMI 30-35 kg/m²) non-smoking men, aged 18-65. Because smoking might influence inflammatory parameters we will use non-smokers.

Exclusion Criteria

- unstable body weight (weight gain or loss >3 kg in the past 3 months)
- Quetelet-index (BMI) < 20 kg/m2 or > 25 kg/m2 or < 30 kg/m2 or > 35 kg/m2
- diabetes mellitus and anti-diabetic medication (e.g. PPARγ agonists)
- severe medical conditions that might interfere with the study such as hypertension, epilepsy, astma, COPD, inflammatory bowel diseases and rheumatoid arthritis, autoimmune disorders, allergies
- use of medication or a diet known to affect serum lipid levels
- history of coronary heart disease
- abuse of drugs and/or alcohol
- smoking
- women
- use of an investigational product within the previous 30 days
- not willing to give up being a blood donor from 4 weeks before the start of the study and during the study.
- impossible of difficult to venipuncture

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>IL-6</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Is there a difference between lean and obese subjects in metabolic risk markers<br /><br>after consuming a low- or high-GI food product?</p><br>