The effect of a low compared to a high glycemic index/saturated fatty acid diet on hepatic fat
- Conditions
- 10013317fatty liverNon-alcoholic fatty liver (NAFL)10019654
- Registration Number
- NL-OMON54906
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 29
- Signed informed consent
- Caucasian (people will be excluded when having a *50% racial African/Asian
background)
- Male or postmenopausal female
- Aged 45-75 years at start of the study
- Body mass index (BMI) 27 * 38 kg/m2
- Stable dietary habits (no weight loss or gain >3kg in the past 3 months)
- Sedentary lifestyle (not more than 2 hours of sports per week)
- TG between 1.0 and 4.0 mmol/L
- Type 2 diabetes
- Any acute condition, exacerbation of chronic condition, or medical history
that would in the investigator*s or dependant physician's opinion interfere
with the study
- Contra-indication for MRI
- Alcohol consumption of >2 servings per day
- Smoking
- Vegetarian, vegan, food intolerant to common foods (e.g. gluten intolerant,
lactose intolerant)
- Use of medication known to interfere with the safety of study procedures
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Liver fat content (measured by 1H-MRS)</p><br>
- Secondary Outcome Measures
Name Time Method <p>Explorative study parameters:<br /><br><br /><br>- de novo lipogenesis (DNL) measured as relative contribution of newly<br /><br>synthesized palmitate in the VLDL-TG pool expressed as %DNL.<br /><br>- hepatic fat oxidation measured as plasma beta-hydroxybutyrate (BHB)<br /><br>- hepatic glycogen content (13C-MRS)<br /><br>- substrate oxidation<br /><br>- plasma metabolites related to energy metabolism<br /><br>- liver fat composition (1 H-MRS)<br /><br>- 24h glycemic response</p><br>