Placenta Development Study

Completed

• Conditions: Healthy

• Registration Number: NCT03614312
• Lead Sponsor: Arkansas Children's Hospital Research Institute

Brief Summary

This study will help us learn more about how the placenta develops.

Detailed Description

The primary purpose of this study is to understand the epigenetic signaling events in placental trophoblast development.

Study Timeline

• Study First Submitted: 2018-03-05
• Study Start: 2018-04-17
• Study First Submitted QC: 2018-07-30
• Study First Posted: 2018-08-03
• Primary Completion: 2021-12-22
• Study Completion: 2021-12-22
• Status Verified: 2023-12
• Last Update Submitted: 2023-12-18
• Last Update Posted: 2023-12-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 15

Inclusion Criteria

• BMI - 18-25 kg/m2
• at least 18 years of age
• singleton pregnancy
• less than 36 weeks and plan to deliver in the Little Rock/North Little Rock Area

Exclusion Criteria

• Women with pre-existing medical conditions (e.g. diabetes, hypertension, pre-eclampsia, STD, gestational diabetes)
• Women who are using recreational drugs, tobacco, or alcohol during their pregnancy.
• Women who plan on keeping their placenta following delivery for non-medical reasons.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of participants that placental syncytial fusion involves epigenetic changes in histone modifications	40 weeks	Number of participants that histone acetyltransferases eszymes, CBP and p300 affect syncytial fusion

Trial Locations

Locations (1)

Arkansas Children's Nutrition Center; 🇺🇸 Little Rock, Arkansas, United States