Effect of Intraperitoneal Nebulisation of Magnesium Sulphate for Analgesia Following Laparoscopic Cholecystectomy

Phase 4

• Conditions: Postoperative Pain
• Interventions: Drug: intraperitoneal nebulisation of magnesium sulphate

• Registration Number: NCT01542697
• Lead Sponsor: B.P. Koirala Institute of Health Sciences

Brief Summary

intraperitoneal nebulisation with magnesuim sulphate will reduce post operative pain and analgesic consumption in postoperative period following laparoscopic cholecystectomy.

Detailed Description

Sixty patients undergoing laparoscopic cholecystectomy belonging to American Society of Anaesthesiologist (I-II) of age 18-65 yrs will be enrolled.Group one (n=30) will receive 1.5 gm magnesium sulphate diluted in 3ml of normal saline and group 2 (n=30) will receive 5 ml of NS.

Study Timeline

• Study Start: 2011-06
• Status Verified: 2012-02
• Study First Submitted: 2012-02-27
• Study First Submitted QC: 2012-02-27
• Last Update Submitted: 2012-02-27
• Study First Posted: 2012-03-02
• Last Update Posted: 2012-03-02
• Primary Completion: 2012-06
• Study Completion: 2012-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

ASA I-II

Exclusion Criteria

history of

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Magnesium sulphate	intraperitoneal nebulisation of magnesium sulphate	intraperitoneal nebulisation of 1.5 gm of magnesium sulphate with 2 ml of normal saline at the end of surgery before closure
normal saline	intraperitoneal nebulisation of magnesium sulphate	intraperitoneal nebulisation of 5 ml of normal saline after end of surgery before closure

Primary Outcome Measures

Name	Time	Method
number of analgesic request	24 hour	time to first analgesic request is taken as duration of effective analgesia; number of analgesic request in first 24 hours were also counted

Secondary Outcome Measures

Name	Time	Method
VAS score	first complaint of pain, 6 hrs, 12 hrs, 24 hrs	Visual analogue scale is a linear 10cm scale with 0 corresponding to no pain and 10 to worst pain ever
nausea and vomiting	24 hrs
respiratory rate	24 hrs
sedation	24hrs

Trial Locations

Locations (1)

routine operation theatre of BPKoirala; 🇳🇵 Dharan, Nepal