Acute effects of dietary proteins, that differ in amino acid composition, on blood pressure-related mechanisms
Recruiting
- Conditions
- Elevated blood pressure10057166
- Registration Number
- NL-OMON36655
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
- healthy overweight men and women (BMI 25-35 kg/m2)
- high normal blood pressure or untreated grade I hypertension (SBP 130-159 mm Hg and/or DBP 85-99 mm Hg)
- age >=20 and <=70 y
- no smoking
- weight stable in last 3 months (± 2 kg)
Exclusion Criteria
- presence of urinary protein (stick test)
- eGFR < 60 ml/min/1.73 m2
- fasting glucose > 7 mmol/L
- use of prescription medication that could influence BP or vascular function
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome parameter is the difference in postprandial vasodilation<br /><br>between the different proteins and the association with differences in the<br /><br>responses of vasodilating factors. </p><br>
- Secondary Outcome Measures
Name Time Method <p>As secondary endpoints, differences in postprandial renal sodium excretion and<br /><br>vascular function changes between protein supplements will be investigated. In<br /><br>addition, differences between protein and carbohydrate intake and between the<br /><br>two carbohydrate sources will be evaluated.</p><br>