Treatment for hypothyroidism with herbal medicine

Phase 2/3

Not yet recruiting

Conditions: Other iodine-deficiency related thyroid disorders and allied conditions. Ayurveda Condition: GALAGANDAH, (2) ICD-10 Condition: E018||Other iodine-deficiency related thyroid disorders and allied conditions. Ayurveda Condition: GALAGANDAH,

Registration Number: CTRI/2023/09/057846

Lead Sponsor: Taranath Goverment Gyurvedic Medical college and hospital bellary

Brief Summary: summary of the study

Hypothyroidism refers to any state that results in the deficiency of thyroid hormone, including hypothalamic or pituitary disease and generalized tissue resistance and autoimmunity to thyroid.it affects approximately one in 10 adults in the study population.female gender and older age were found to have significant association with hypothyroidism

Basti helps to convert dysbiotic state of intestinal flora in symbiotic stae so for that region considered basti in this study for intervention.basti acts at enteric nervous system and influences cellular level and stimulate HPT axis by virtue of thyroid gut connection by gut microbiota modulation.gomutra mandooram contains mandoora triphala, trikatu,chavya which are kaphavatajara,does amapachana,agnideepana and shothahara.guda haritaki is rasayana, promotes anabolism of healthy dhatu,does deepana ,doshanulimana so study is undertaken for assessment of combined efficacy of gomutra mandooram, ayugma aragwadhadi kashaya basti and guda haritaki rasayana in the management of Hypothyroidism

Objective of the study

1. To evaluate the combined efficacy of gomutra mandooram, ayugma aragwadhadi kashaya basti and guda haritaki rasayana in the management of Hypothyroidism

2. To assess the effect of modern ongoing treatment in the management of Hypothyroidism

3. To compare the combined effect of gomutra mandooram, ayugma aragwadhadi kashaya basti and guda haritaki rasayana over modern ongoing treatment for hypothyroidism

*Study design*

Study type: randomised clinical trial, comparative prospective

Estimated enrollment -80

Interventional model-2 group assignment

Allocation -Randomized

Study duration -63 days

Masking-open

Follow up after-15 days

Assessment criteria

1. High TSH level(as per report/evaluator)

2. Symptoms like kesha chyuthi,klama,angamarda,aniyata arthava etc

3. Correct of thyroid profile

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 80

Inclusion Criteria

Subjects who are diagnosed with Hypothyroidism with or without medicine and with or without washout period.
TSH value more than 5mIU/ml Subjects between the age of 18 to 60 years.
Subjects who are fit for Basti Karma.
Those subjects who are ready to sign informed consent form.

Exclusion Criteria

Diagnosed cases of cardiac disease, congenital anomalies.
Patients suffering from congenital Hypothyroidism and carcinoma of the thyroid gland, Thyroid nodules,goiter, Thyroiditis, myxedema, and its complication, thyrotoxicosis, post-operative hypothyroidism, hypothyroidism post radio iodine therapy, hypothyroidism in pregnancy,lactating woman.
Also the subjects suffering from severe systemic disorders which interferes with course of intervention will be excluded.
Those who are not fit for Basti karma.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
qualitive of life improvements	8 weeks
correction of TSH level	8 weeks

Secondary Outcome Measures

Name	Time	Method
Correction of TSH level	Imrovement in QOL
Improvement of Hb%	Improvement of subjective parameters

Trial Locations

Locations (1): Taranath goverment ayurvedic medical college and hospital bellary 583101
🇮🇳
Bellary, KARNATAKA, India
Taranath goverment ayurvedic medical college and hospital bellary 583101
🇮🇳Bellary, KARNATAKA, India
Dr Jaishree
Principal investigator
8050047304
jaishreebiradar18@gmail.com