Comparison of efficacy of concentration with volume of local anaesthetics in femoral-sciatic blocks for total knee replacement - Local anaesthetics
Phase 1
- Conditions
- o medical condition or disease under investigation.MedDRA version: 9.1 Level: LLT Classification code 10002182 Term: Analgesia
- Registration Number
- EUCTR2009-011233-27-GB
- Lead Sponsor
- orth Wales NHS Trust
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
ASA 1 and 2 adult patients undergoing elective total knee replacement.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Children < 18 years old.
Pregnant women
Patients with contraindications to local anaesthetic, eg anaphylaxis
Patients unable to give informed consent.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: We propose to look at 2 groups of patients to compare the efficacy of concentration vs volume of local anaesthetics in the sciatic component of the femoral-sciatic block in patients requiring total knee replacement. Is postoperative analgesic effect similar in both groups?;Secondary Objective: Side effects such as motor blockade.;Primary end point(s): 24 hours post operation.
- Secondary Outcome Measures
Name Time Method