Potassium handling in chronic hemodialysis patients in response to higher dialysate potassium

Recruiting

• Conditions: CKD-5D; End-Stage-Renal-Disease; 10029149

• Registration Number: NL-OMON55533
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

• Adult (age >= 18 years) stable anuric hemodialysis patients that undergo
treatment 3 x 4 hrs/week.
• Written informed consent

Exclusion Criteria

• Pre-dialysis serum potassium <4.0 mmol/L or > 6.0 mmol/L or use of potassium
binders
• Patients with previous history of ventricular cardiac arrhythmia.
• Uncontrolled hypertension (systolic BP >180 mmHg on at least 3 of the last 5
dialysis treatments) or intradialytic hypotension on >3 dialysis treatments in
the last month
• Patients with insulin dependent diabetes mellitus
• Patients with a life expectancy < 6 months.
• Expected kidney transplantation < 2 months.
• Cognitively impaired or incapacitated subjects.
• Women who are pregnant, breastfeeding or consider pregnancy in the coming 6
months.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome will be RBC potassium (mmol/L)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints will include serum potassium, potassium removal, serum<br /><br>sodium, sodium removal, total ultrafiltration volume, total body water, and<br /><br>systolic blood pressure as well as changes in serum bicarbonate, insulin, and<br /><br>plasma aldosterone.</p><br>