Potassium handling in chronic hemodialysis patients in response to higher dialysate potassium
Recruiting
- Conditions
- Chronic Kidney Disease, End-Stage Renal Disease
- Registration Number
- NL-OMON23110
- Lead Sponsor
- AUMC - AMC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 24
Inclusion Criteria
•Adult (age = 18 years) stable anuric hemodialysis patients that undergo treatment 3 x 4 hrs/week.
•Written informed consent
Exclusion Criteria
•Pre-dialysis serum potassium < 4.0 mmol/L or > 6.0 mmol/L or use of potassium binders
•Patients with previous history of ventricular cardiac arrhythmia
•Uncontrolled hypertension (systolic BP >180 mmHg on at least 3 of the last 5 dialysis treatments) or intradialytic hypotension on >3 dialysis treatments in the last month
•Patients with insulin dependent diabetes mellitus
•Patients with a life expectancy < 6 months
•Expected kidney transplantation < 2 months
•Cognitively impaired or incapacitated subjects.
•Women who are pregnant, breastfeeding or consider pregnancy in the coming 6 months.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome will be RBC potassium.
- Secondary Outcome Measures
Name Time Method Secondary endpoints will include serum potassium, potassium removal, serum sodium, sodium removal, total ultrafiltration volume, total body water, and systolic blood pressure as well as changes in serum bicarbonate, insulin, and plasma aldosterone.<br>