Effect of Thoracic Epidural Analgesia for Thoracic Surgery on Arrhythiogenesis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Occurrence of AF
研究概览
简要总结
Thoracic epidural anesthesia and analgesia for patients undergoing lung resection can reduce the occurrence of AF if it is continued for six postoperative days instead of just three.
详细描述
THEA is considered a very effective technique of providing intra and post-operative analgesia for thoracic surgical procedure and it seems that can also be effective in reducing the incidence of postoperative AF in patients undergoing lung resection. Nevertheless the timing of stopping the epidural analgesia and its further substitution with other therapies, remains unclear.
In this study patients who are scheduled for lung resection surgery will undergo the surgery under combined general anesthesia with volatile anesthetics and thoracic epidural anesthesia.
Immediately after surgery the patients will be divided into two groups:
- those who will receive thoracic epidural analgesia for 6 days
- those who will receive thoracic epidural analgesia for 3 days and will then switch to intravenous morphine for another 3 days
All the patients will be monitored daily for arrythmias
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •lung resection
- •pneumonectomy
排除标准
- •Patient refusal
- •AF (present or in the past
- •contraindications for epidural catheter placement
结局指标
主要结局
Occurrence of AF
时间窗: 6 postoperative days
Every day, for the first 6 postoperative days, the investigators will record an ECG of the patient, and look after for any presence of AF
次要结局
- Quality of analgesia(6 postoperative days)
研究者
Metaxia Bareka
Anesthesiologist
Larissa University Hospital