The influence of the oral microbiome on the pathophysiology of Alzheimer's disease

• Conditions: F00.0; F00.1; Dementia in Alzheimer disease with early onset; Dementia in Alzheimer disease with late onset

• Registration Number: DRKS00023456
• Lead Sponsor: Deutsche Alzheimer Gesellschaft e. V. Selbsthilfe Demenz, vertreten durch die Geschäftsführerin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-11-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Women and men (> 65 years) with mild AD (MMST = 20)
- Women and men (> 65 years) with MCI and a pathological CSF profile (Aß1-42 decreased, tau protein increased)
- Women and men (> 65 years) as healthy control subjects (MMST> 27)
- Obtained consent and information ability
- Willingness to take swabs of the oral mucosa and gums

Exclusion Criteria

- Acute infections of the upper respiratory tract
- Known acute inflammations in the oral cavity (e.g. stomatitis)
- Serious physical illnesses with impairment of the general condition, fever or current weight loss of more than 2 kg in the past four weeks, palliative life situation
- Malnutrition (body mass index below 18.5 kg / m2)
- Other neurological diseases (stroke, multiple sclerosis, epilepsy, Parkinson's disease) or severe psychiatric comorbidities such as an addiction disorder or schizophrenic psychosis
- Potentially reversible causes of cognitive deficits (e.g. vitamin B12 deficiency)

Study & Design

• Study Type: observational
• Study Design: Not specified