ISRCTN34153772已完成未知
A randomised controlled trial of topical intranasal tranexamic acid versus placebo to reduce the need for nasal packing in patients presenting to the Emergency Department with spontaneous epistaxis
Royal Devon and Exeter NHS Foundation Trust0 个研究点目标入组 496 人开始时间: 2017年6月1日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 496
研究概览
简要总结
2019 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/30772866 protocol 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33612282/ (added 06/07/2021)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Aged 18 or over, any gender
- •2. Presenting to the ED with spontaneous, atraumatic epistaxis, unresolved with simple first aid and standard initial therapy
排除标准
- •1. Clinical evidence of shock, as determined by the treating clinician, or requirement for resuscitation (including but not limited to systolic BP< 90 mmHg).
- •2. Known allergy to TXA
- •3. Lacking capacity
- •4. Unwilling to give consent
- •5. No telephone or unwilling to be contacted by telephone
- •6. Known paranasal, nasopharyngeal or nasal cavity malignancy
- •7. Pregnancy
- •8. Sent to ED for specialist ENT treatment
- •9. Already undergone pre-hospital nasal packing
- •10. Prior participation in the study (i.e. received allocated treatment)
- •11. Prisoners
- •12. Epistaxis caused by trauma (excluding simple nose picking)
- •13. Known haemophilia
研究者
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