ISRCTN34153772
Completed
未知
A randomised controlled trial of topical intranasal tranexamic acid versus placebo to reduce the need for nasal packing in patients presenting to the Emergency Department with spontaneous epistaxis
Royal Devon and Exeter NHS Foundation Trust0 sites496 target enrollmentJune 1, 2017
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
- Enrollment
- 496
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
2019 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/30772866 protocol 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33612282/ (added 06/07/2021)
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Aged 18 or over, any gender
- •2\. Presenting to the ED with spontaneous, atraumatic epistaxis, unresolved with simple first aid and standard initial therapy
Exclusion Criteria
- •1\. Clinical evidence of shock, as determined by the treating clinician, or requirement for resuscitation (including but not limited to systolic BP\< 90 mmHg).
- •2\. Known allergy to TXA
- •3\. Lacking capacity
- •4\. Unwilling to give consent
- •5\. No telephone or unwilling to be contacted by telephone
- •6\. Known paranasal, nasopharyngeal or nasal cavity malignancy
- •7\. Pregnancy
- •8\. Sent to ED for specialist ENT treatment
- •9\. Already undergone pre\-hospital nasal packing
- •10\. Prior participation in the study (i.e. received allocated treatment)
Outcomes
Primary Outcomes
Not specified
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Unknown
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