Analytic Treatment Interruption (ATI) to Assess HIV Cure

Not Applicable

• Conditions: HIV
• Interventions: Other: Analytic treatment interruption

• Registration Number: NCT02437526
• Lead Sponsor: Mayo Clinic

Brief Summary

This study is designed to determine if individual patients with HIV infection have been cured of the infection. To do this, antiretroviral therapy is discontinued under close medical supervision and the patient monitored over time for reactivation of infection.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-05
• Study First Submitted: 2015-05-05
• Study First Submitted QC: 2015-05-06
• Study First Posted: 2015-05-07
• Status Verified: 2025-06
• Last Update Submitted: 2025-06-03
• Last Update Posted: 2025-06-05
• Primary Completion: 2035-05
• Study Completion: 2035-05

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Treatment interruption	Analytic treatment interruption	Antiretroviral therapy will be discontinued under close laboratory monitoring and clinical supervision.

Primary Outcome Measures

Name	Time	Method
Time to virologic rebound	38 weeks

Secondary Outcome Measures

Name	Time	Method
Time to HIV-1 RNA ≥ 20 copies/ml	38 weeks
Time to HIV-1 RNA ≥ 100 copies/ml	38 weeks

Trial Locations

Locations (1)

Mayo Clinic in Rochester; 🇺🇸 Rochester, Minnesota, United States