Angiomatoid Fibrous Histiocytoma: a Single Institution Case-series
- Conditions
- Angiomatoid Fibrous Histiocytoma
- Registration Number
- NCT03759327
- Lead Sponsor
- Istituto Ortopedico Rizzoli
- Brief Summary
single institution cases series review of histological and clinical data
- Detailed Description
single institution cases series review of histological and clinical data Investigators will retrieve from the archives of the Rizzoli Institute all the cases with a histological diagnosis of Angiomatoid Fibrous Histiocytoma. In all cases with enough available material, immunohistochemistry will be performed on slides/formalin-fixed paraffin-embedded tissue tumor material.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 9
- Male and female patients treated at Rizzoli Institute from 01 January 2006 to 31 December 2017
- Diagnosis of Angiomatoid Fibrous Histiocytoma
- Histological slides/formalin-fixed paraffin-embedded tissue tumor (FFPE) blocks from archive available to perform the histology analysis
- Written informed consent prior to any study-specific analysis and/or data collection
• Patients with histological diagnosis different from Angiomatoid Fibrous Histiocytoma
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method selection and review of 9 cases of Angiomatoid Fibrous Histiocytoma at baseline (Day0) investigators will review all the medical records, radiological imaging, and histological slides of all cases to identify the best therapeutic approach.
analysis of EWS-CREB1 and EWS-ATF1 mutation and ALK expression on tissue tumor material at baseline (Day0) In all cases immunohistochemistry will be performed on slides/formalin-fixed paraffin-embedded tissue tumor material. EWS-CREB1 and EWS-ATF1 mutation and ALK expression will be analyzed with RT-PCR and/or FISH analysis.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
IRCC Rizzoli Orthopedic Institute
🇮🇹Bologna, Italy