Epithelioid Hemangioma of Bone And Soft Tissue

Completed

• Conditions: Epithelioid Hemangioma of Bone; Epithelioid Hemangioma

• Registration Number: NCT03169595
• Lead Sponsor: Istituto Ortopedico Rizzoli

Brief Summary

The controversy surrounding epithelioid hemangioma diagnosis stems from its somewhat aggressive clinical characteristics, including multifocal presentation and occasional lymph node involvement.

The investigators reviewed the clinicopathologic and radiologic characteristics of bone and soft tissue epithelioid hemangioma in patients treated at our institution with available tissue for molecular testing.

The hypothesis is that epithelioid hemangioma may present with multifocal involvement and rare loco-regional lymph node metastasis, but it remains a benign tumor with excellent prognosis.

Detailed Description

The investigators retrospectively reviewed patients treated for epithelioid hemangioma of the bone and soft tissue in a single insitution. The purpose of this study is to evaluate the pathological, clinical, and radiological characteristics of epithelioid hemangioma arising within bone and soft tissue, in the first cohort of cases where the definitive diagnosis is supplemented by molecular techniques.

The hypothesis is that the improved knowledge regarding this rare entity can more definitively elucidate the benign biology of epithelioid hemangioma.

Study Timeline

• Study Start: 2015-10-07
• Status Verified: 2017-05
• Primary Completion: 2017-05-17
• Study Completion: 2017-05-17
• Study First Submitted: 2017-05-17
• Study First Submitted QC: 2017-05-26
• Last Update Submitted: 2017-05-26
• Study First Posted: 2017-05-30
• Last Update Posted: 2017-05-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• patients with epithelioid hemangioma of bone and soft tissue in the extremities and pelvis

Exclusion Criteria

• patients with epithelioid hemangioma of bone and soft tissue in the spine

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Multifocal presentation of patients with epithelioid hemangioma of bone and soft tissue without producing a fatal outcome	2 years	The investigators defined multifocal presentation the presence of secondary lesions by imaging at presentation of the disease or during follow-up.