Alterations of Immunologic Mediators During Severe Sepsis

Terminated

• Conditions: Severe Sepsis

• Registration Number: NCT00484146
• Lead Sponsor: Klinikum St. Georg gGmbH

Brief Summary

Severe sepsis induces significant changes in expression of insulin- and toll-like receptors, cytokines, markers of apoptosis, and activation of t- and b-lymphocytes.

Detailed Description

In patients at early stage of severe sepsis, we investigate the expression of pro- and anti-inflammatory cytokines, chemokines, adhesion-molecules, toll-like receptors, insulin-receptors, markers of apoptosis und of t- and b-cell-activation on a mRNA level.

Study Timeline

• Study Start: 2006-06
• Study First Submitted: 2007-06-07
• Study First Submitted QC: 2007-06-07
• Study First Posted: 2007-06-08
• Primary Completion: 2012-12
• Study Completion: 2012-12
• Status Verified: 2017-02
• Last Update Submitted: 2017-02-07
• Last Update Posted: 2017-02-09

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• age >= 18 y
• agreement with study procedures
• 3 of 4 SIRS-criteria
• proven or highly suspected infection
• 2 or more sepsis-induced organ failures
• start of first sepsis-induced organ failure within the last 36 hours

Exclusion Criteria

• non-agreement with study procedures
• signs of severe sepsis with organ failure > 36 hours
• chronic immuno-compromising diseases
• chronic therapy with anti-inflammatory drugs
• non-curable cancer
• chronic renal failure with hemodialysis
• pregnancy or breast-feeding

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
severity of sepsis	96 hours after diagnosis of sepsis	SOFA-Score

Trial Locations

Locations (1)

Klinikum St. Georg gGmbH, Interdisciplinary Intensive Care Unit; 🇩🇪 Leipzig, Sachsen, Germany