The effects of antithymocyte globulin (ATG) on the endothelial glycocalyx in kidney transplant recipients

• Conditions: endothelial glycocalyx and atherosclerosis; 10003216; 10038430

• Registration Number: NL-OMON34735
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 6

Inclusion Criteria

Female or male, age between 18 and 70 years
Kidney transplant recipient
ATG therapy because of an allograft rejection
Given written informed consent

Exclusion Criteria

Smoking
Diabetes Mellitus

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The thickness of the endothelial glycocalyx in kidney transplant recipients<br /><br>before and after ATG therapy. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The following parameters will be measured:<br /><br><br /><br>- Glycocalyx constituents and glycocalyx regulating enzymes: hyaluronan,<br /><br>heparan sulfate, syndican-1, hyaluronidase en heparanase<br /><br>- IL-6, CRP</p><br>