Genicular Nerve Block for Knee Pain in the ED

Not Applicable

Recruiting

• Conditions: Knee Pain

• Registration Number: NCT07158736
• Lead Sponsor: University of Pennsylvania

Brief Summary

Patient with atraumatic knee pain without a large knee effusion on x-ray will be randomized to receive either a genicular nerve block (GNB) or standard of care in the emergency department.

Detailed Description

Not available

Study Timeline

• Study Start: 2025-07-16
• Study First Submitted: 2025-07-17
• Status Verified: 2025-09
• Study First Submitted QC: 2025-09-02
• Last Update Submitted: 2025-09-02
• Study First Posted: 2025-09-08
• Last Update Posted: 2025-09-08
• Primary Completion: 2026-08-01
• Study Completion: 2026-09-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• Atraumatic knee pain
• >17 years age
• X-ray of the knee obtained in the ED
• Initial pain score (numeric rating scale) 5-10

Exclusion Criteria

• Fracture or dislocation on x-ray
• large knee joint effusion identified on x-ray
• allergy or contraindication to local anesthetics
• History of local anesthetic systemic toxicity after receiving local anesthetics
• Pregnancy
• Incarcerated
• History of knee replacement of affected knee
• Concern for septic joint
• Overlying cellulitis
• Hemodynamic instability
• Altered mental status or inability to consent for procedure.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Pain level	1 hour post-enrollment	Measured by numeric rating scale: 0 (minimum value) - 10 (maximum value)

Secondary Outcome Measures

Name	Time	Method
Difference in Duration of Analgesia	24 hours	Patients will be called back to assess their pain levels
Difference in AP-POQ-RED score	1 hour after enrollment	9 question survey study, all questions rated on 0 (minimum) - 10 (maximum) scale. Questions include: pain before and after treatment, pain with activities in and out of bed, emotions (anxiety, fear, helplessness), degree of pain relief in the emergency department, satisfaction.
Difference in length of stay in the emergency department	Average 1 hour	Length of stay in the emergency department is determined from the time the provider first sees the patient to the time the provider discharges the patient.

Trial Locations

Locations (4)

Hospital of the University of Pennsylvania; 🇺🇸 Philadelphia, Pennsylvania, United States

Pennsylvania Hospital; 🇺🇸 Philadelphia, Pennsylvania, United States

Pennsylvania Presbyterian Medical Center; 🇺🇸 Philadelphia, Pennsylvania, United States

HUP Cedar; 🇺🇸 Philadelphia, Pennsylvania, United States