To compare which of the two nerve blocks is better in decreasing pain after total knee replacement surgery- adductor canal nerve block alone or adductor canal nerve block and genicular nerve block combined.

Not yet recruiting

Conditions: Unilateral primary osteoarthritisof knee,

Registration Number: CTRI/2022/11/047318

Lead Sponsor: Dr Prateek Mitra

Brief Summary: We will conduct a radomized, double-blind, placebo-controlled trial to hypothesize that genicular nerve blockade (GNB), performed in addition to the standard adductor canal regimen would result in a reduction in 24 hours opioid consumption following total knee replacement surgery. Due to the selective blockade of articular branches and motor sparing effect, GNB can possibly be helpful in early ambulation and faster discharge of the patient following total knee replacement surgery.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 50

Inclusion Criteria

1.American Society of Anaesthesiologists physical status (ASA) I-III 2.Aged 40 years and above.
Patients scheduled for unilateral, primary, total knee replacement under spinal anaesthesia 4.Patients who agree to participate in the study.

Exclusion Criteria

1.Patient refusal to participate 2.Contraindication to spinal anaesthesia or peripheral nerve blocks (local infection, neurologic deficit or disorder) 3.Patients with significant level of cognitive impairment (inability to communicate pain scores or the need of analgesia) 4.Patients on opioids for chronic pain 5.Revision knee surgery or bilateral TKR 6.History of psychiatric illness 7.Previous trauma or surgery of ipsilateral knee 8.Severe cardiovascular disease and renal disease 9.History of gastrointestinal bleeding or acid peptic disorder.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The cumulative opioid consumption in the first 24 hours	First 24 hours following surgery

Secondary Outcome Measures

Name	Time	Method
-Visual analogue score (VAS) at rest and on passive 15Â° limb lifting at 3, 6,12 and 24 hours postoperatively.	-Time to first rescue analgesic request

Trial Locations

Locations (1): PRADYUMNA BAL MEMORIAL HOSPITAL, KALINGA INSTITUTE OF MEDICAL SCIENCES
🇮🇳
Khordha, ORISSA, India
PRADYUMNA BAL MEMORIAL HOSPITAL, KALINGA INSTITUTE OF MEDICAL SCIENCES
🇮🇳Khordha, ORISSA, India
Dr Ganesh Chandra Satapathy
Principal investigator
8283872939
ganesh.satapathy@kims.ac.in