Effect of Prednisolone Treatment on Uterine Natural Killer Cells
- Registration Number
- NCT03902912
- Lead Sponsor
- Chinese University of Hong Kong
- Brief Summary
This study aims to investigate the role of uNK cells and the association with prednisolone.
- Detailed Description
Glucocorticoids prednisolone is considered as a potential therapy in women with recurrent miscarriage. However, the evidence for treatment with prednisolone is still inconclusive and the relevant mechanism merits further investigations.
The participants will be invited to take prednisolone oral 10 mg/day and attend our outpaitent clinic to be performed endometrial biopsy.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 84
Inclusion Criteria
- Women with a history of 3 or more consecutive miscarriages
- Women younger than 40 years old
Exclusion Criteria
- Allergy to prednisolone
- Women who have any uterine anomaly
- Antiphospholipid syndrome
- Hydrosalpinx
- Thrombophilia
- Abnormal thyroid function tests
- women with diabetes,
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description prednisolone Prednisolone prednisolone oral 10 mg/day from day one of the subsequent menstrual cycle to day LH plus 7. Women will be then given a tailing off dose of 5 mg/day for 3 days followed by 2 mg/day for 3 days and then 1 mg/day for 3 days.
- Primary Outcome Measures
Name Time Method the number of uNK cells at the 1 day of endometrial biopsy to investigate the association between uNK cells and prednisolone
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
The Chinese University of Hong Kong
ðŸ‡ðŸ‡°Hong Kong, Hong Kong