Detecting Musculoskeletal Parameters by Magnetic Resonance Imaging for Biomechanical Models

Completed

• Conditions: Geen, niet gericht op aandoeningen; N.A.

• Registration Number: NL-OMON39569
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

We will include 30 subjects for the screening (step 1). Subjects will perform a standard maximal voluntary isometric knee extension on the biodex (step 2). Thereafter all 30 subjects will be arranged from low to high maximal isometric knee extension torque. Based on their maximal knee extension torque 10 subjects will be selected. From the male participants one with the highest maximal torque and one with the lowest maximal torque and three intermediate will be selected. The same selection will be performed for the female participants. These 10 participants will complete the MRI-protocol and the measurements at the Department of Human Movement Sciences (step 3). Based on this wide variety of strength between subjects, a high diversity of personalized models can be tested. Furthermore, the subjects should be between 18 and 65 years of age and should be able to complete all tests, instructed by the researcher. Finally we will select 5 subjects in the reproducibility study (step 4), who finished step 3.

Exclusion Criteria

Clinical exclusion criteria: all musculoskeletal disorders of the lower extremities, which still affect their locomotion, prosthesis on the lower limbs and mental illnesses with visible changes of activities in daily living (walking, stair walking and chair raising). MRI exclusion criteria: weight > 150 kg, claustrophobia, pacemaker, pregnancy or breastfeeding. Electro stimulation exclusion criterion: pacemaker. Finally, volunteers older than 65 will be excluded, because of an increased risk of musculoskeletal disorders, and a decreased ability to exert full muscle potential.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>MRI Parameters:<br /><br>- Individual muscle volumes<br /><br>- Fiber trajectory<br /><br>- Fiber length<br /><br>- Physiological cross sectional area<br /><br>- Attachement points (origo + insertion of muscles)<br /><br>- Bone gyometry<br /><br><br /><br>Biomechanical parameters<br /><br>- Maximal contractions (voluntary and including electronic stimulation)<br /><br>- Muscle activities during activities of daily living (ADL-tasks)<br /><br>- kinematic parameters during ADL-taken<br /><br>- kinetic parameters during ADL-taken</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>N.A.</p><br>