Magnetic Resonance flow measurements of mesenteric arteries and veins and portal vein with food stimulation and mitochondrial oxygen measurements during routine upper endoscopy in patients suspected of chronic gastro-intestinal ischemia

Recruiting

Conditions: chronic gastro-intestinal ischemia
10018031
oxygen deficiency of the gastro-intestinal tract

Registration Number: NL-OMON55671

Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 62

Inclusion Criteria

1. Patients suspected of CGI referred to our hospital for further analysis
2. Age >= 18 years
3. Patients who gave informed consent

Exclusion Criteria

1. Age < 18 years
2. Unable to give informed consent
3. Pregnancy
4. Contra-indications for MRI:
a. Metal implants which cannot be removed. E.g. cardiac pacemakers/ICD,
aneurysm clips, metal stents, artificial heart valve, cochlea/retinal implants,
hearing aids, dentures with magnetic click system or with other metal
accessories, tattoos with metallic dye, metal plates/pins/screws of bones,
piercings
b. Claustrophobia
c. Inability to lie still for 1 hour to 1,5 hours
5. Other criteria the physician considers are not compatible with this study
6. Contra-indications for MitoO2 measurements:
a. Acute or chronic porphyria
b. Hypersensitivity for ALA or porphyrin
c. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline
phosphatase (ALP), or bilirubin of >2 times upper limit of normal

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- To determine the difference in baseline MR flow measurements and post<br /><br>prandial MR flow measurements between patients diagnosed with CGI and patients<br /><br>not diagnosed with CGI<br /><br>- To gather information on the potential of endoscopic mitochondrial oxygen<br /><br>measurements in diagnosing CGI in patients suspected of CGI.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- To determine which vessel or which combination of vessels best differentiates<br /><br>between patients diagnosed with CGI and patients not diagnosed with CGI by MR<br /><br>flow measurement<br /><br>- The severity of abdominal pain in course of time after stimulation with<br /><br>nutritional drink, using the Numeric Pain Intensity scale at baseline and 20,<br /><br>30 and 40 minutes after nutritional drink.<br /><br>- To determine the difference in MR flow measurements of the mesenteric vessels<br /><br>prior to and after treatment in patients diagnosed with CGI with persistent<br /><br>relief of symptoms after treatment.</p><br>