Comparison of the Duration of Ropivacaine Combined With Dexmedetomidine or Dexamethasone on Paravertebral Block in Patients Undergoing Video-assisted Thoracic Surgery
Overview
- Phase
- Phase 4
- Intervention
- Dexmedetomidine Group
- Conditions
- Lung Cancer
- Sponsor
- China Medical University, China
- Enrollment
- 154
- Locations
- 1
- Primary Endpoint
- Change of thoracic paravertebral block analgesia duration
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
This study was a prospective, randomized, controlled, and double-blind trial. Major assessments were made during the operation and 48 h postoperatively.
Detailed Description
The prime outcomes were the time in minutes from leave the postoperative care unit to the first patient-controlled intravenous analgesia press.The secondary outcomes were to compare the following: (1)blood concentrations of ropivacaine was measured at 0.5 h, 1 h, 2 h, 3 h, and 24 h after paravertebral nerve block; and (2) the patient's intraoperative opioid use, phenylephrine use, fluid intake, urine output, dry mouth score, and 24 h and 48 h visual analogue scale.
Investigators
Wen-fei Tan
Professor
China Medical University, China
Eligibility Criteria
Inclusion Criteria
- •(1) age 18 to 65 years,
- •(2) scheduled to undergo video-assisted thoracic surgery,
- •(3) American Society of Anesthesiologists risk classification I-II.
Exclusion Criteria
- •(1) patient refusal;
- •(2) known hypersensitivity to the study medication (ropivacaine);
- •(3) long-term use of opioids;
- •(4) liver or renal insufficiency;
- •(5) a history of psychiatric or neurological disease;
- •(6) deafness;
- •(7) regular use of acetaminophen, nonsteroidal anti-inflammatory drugs, corticosteroids, or antiemetics; and
- •(8) a preoperative Pittsburgh Sleep Quality Index (PSQI) global score higher than 6.
Arms & Interventions
dexmedetomidine group
thoracic paravertebral blocks using a combination of ropivacaine and dexmedetomidine 100 ug every time
Intervention: Dexmedetomidine Group
dexamethasone Group
thoracic paravertebral blocks using a combination of ropivacaine and dexamethasone 10 mg every time
Intervention: dexamethasone group
control group
thoracic paravertebral blocks using only ropivacaine
Intervention: control group
Outcomes
Primary Outcomes
Change of thoracic paravertebral block analgesia duration
Time Frame: Change from Baseline to 2 days after surgery
The prime outcomes were the time in minutes from leave the postoperative care unit to the first patient-controlled intravenous analgesia press
Secondary Outcomes
- blood concentrations of ropivacaine(Change from Baseline to 2 days after surgery)