The Effect of Combining Lidocaine and Ropivacaine on the Duration and Onset Time of an Ultrasound-guided Infraclavicular Brachial Plexus Nerve Block. a Randomized Controlled Trial
Overview
- Phase
- Phase 3
- Intervention
- Ropivacaine 0.5% Injectable Solution
- Conditions
- Nerve Block
- Sponsor
- Nordsjaellands Hospital
- Enrollment
- 78
- Locations
- 1
- Primary Endpoint
- Total time to breakthrough pain
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The aim of the study is to investigate how the combination of ropivacaine (a slow onset, long duration local anesthetic) with lidocaine (a rapid onset, shorter duration local anesthetic) affects the onset and duration of a lateral infraclavicular plexus brachialis (LIC) block in patients undergoing non-acute hand surgery.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Scheduled for non-acute hand surgery in regional anesthesia
- •Scheduled for surgery on one of the following: 1) Antebrachium fractures or 2) Arthroplasty of a thumb base joint or 3) alloplasty of a thumb base joint
Exclusion Criteria
- •BMI \> 40 kg/m2
- •Weight \< 60 kg
- •Age \< 18 years
- •ASA physical status classification system grade \> 3
- •Allergy to experimental drugs
- •Patients who cannot cooperate with the examinations or treatment
- •Patients who do not understand or speak Danish
- •Patients with peripheral or central neurological disease or nerve damage with neurological effect on the upper extremity, where surgery is required
Arms & Interventions
Control group: Ropi-5
30 ml Ropivacaine 5 mg/ml (equivalent to 150 mg Ropivacaine)
Intervention: Ropivacaine 0.5% Injectable Solution
Intervention group 1: Ropi-5+Lido-20
20 mL Ropivacaine 5 mg/ml + 10 mL Lidocaine-Epinephrine (20 mg + 5 µg) /ml (= 100 mg Ropivacaine + 200 mg Lidocaine)
Intervention: Ropivacaine 0.5% Injectable Solution
Intervention group 1: Ropi-5+Lido-20
20 mL Ropivacaine 5 mg/ml + 10 mL Lidocaine-Epinephrine (20 mg + 5 µg) /ml (= 100 mg Ropivacaine + 200 mg Lidocaine)
Intervention: Lidocaine epinephrine
Intervention group 2: Ropi-7.5+Lido-20
20 mL Ropivacaine 7,5 mg/mL + 10 mL Lidocaine-Epinephrine (20 mg + 5 µg) /ml (= 150 mg Ropivacaine + 200 mg Lidocaine)
Intervention: Lidocaine epinephrine
Intervention group 2: Ropi-7.5+Lido-20
20 mL Ropivacaine 7,5 mg/mL + 10 mL Lidocaine-Epinephrine (20 mg + 5 µg) /ml (= 150 mg Ropivacaine + 200 mg Lidocaine)
Intervention: Ropivacaine 0.75% Injectable Solution
Outcomes
Primary Outcomes
Total time to breakthrough pain
Time Frame: 24 hours
From the completion of the LIC block to first sensation of pain from the surgical area.
Secondary Outcomes
- Total duration of sensory blockade(24 hours)
- Total duration of motor blockade(24 hours)
- The onset of sensory block(Until max 45 minutes)
- Degree of motor blockade(At complete sensory blockade and otherwise 45 minutes after block performance)